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KMID : 0604520080340030217
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Journal of the Society of Cosmetic Scientists of Korea
2008 Volume.34 No. 3 p.217 ~ p.223
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Inhibitory Effects of Tannic acid on Human Skin Fibroblast Elastase Activity
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Lee Ju-Eun
Kim So-Young
Kim Su-Yeon
Oh Mi-Hee
Yun Hye-Young
Baek Kwang-Jin
Kwon Nyoun-Soo
Kim Dong-Seok
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Abstract
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Elastin is an important component of elastic fibers in the skin. Recently, many studies have reported that elastin is also involved In inhibiting or repairing wrinkle formation, although collagen is a major factor in the skin wrinkle formation. Elastase is a metalloproteinase which acts on degradation of elastin. It is known that elastase activity is increased by ultraviolet (UV) B radiation. Thus, Increased elastase activity could be the major reason for skin elasticity reduction and winkle formation. Tannic acid is a polyphenol found in various fruits and nuts. This molecule has a potent ability to eliminate reactive oxygen species and reactive nitrogen species. In the present study, we investigated whether tannic acid has effects on elastase activity and tropoelastin synthesis. Our results showed that tannic acid reduced elastase activity significantly in a dose-dependent manner. However, the expression of tropoelastin protein and mRNA was not significantly affected by tannic acid. From these results, we suggest that tannic acid may contribute to block tortuosity of elastic fibers by inhibiting elastase. Thus, tannic acid might be developed for a possible agent to Inhibit skin aging.
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KEYWORD
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human fibroblast, elastase, elastin, tannic acid, tropoelastin
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